<b>Alergia a la proteína de la leche de vaca </b>
PDF
XML

Palabras clave

Alergia a la proteína de la vaca
Inmunoglobulina E
Alérgenos
Lactantes

Cómo citar

Alergia a la proteína de la leche de vaca . (2025). Revista Alergia México, 72(4), 318-330. https://doi.org/10.29262/ram.v72i4.1473

Resumen

La alergia a la proteína de la leche de vaca es el nombre que se le otorga a la reacción adversa derivada de los componentes proteicos de este líquido. La leche contiene proteínas con potencial alergénico, que se clasifican en caseínas y las proteínas del suero. En particular la α-lactoalbúmina y la β-lactoglobulina, presentes en el suero, pueden ser responsables de una respuesta inmunológica específica mediada o no por inmunoglobulina E (IgE). La superación de este tipo de alergia mediante la adecuada alimentación de la madre puede traducirse en lograr tolerancia oral mediada por la lactancia materna. La lactancia materna no sólo provee una adecuada alimentación sino del desarrollo de microbiota intestinal. Ambos elementos: microflora y proceso de la tolerancia oral mediada por la leche materna, permiten aportar además una carga mínima de alérgenos, según lo demostrado aún en modelos de laboratorio (ratones). La presente revisión muestra los antecedentes técnicos de la alergia a la proteína de la leche de vaca.

Palabras clave: Alergia a la proteína de la vaca (APLV); Inmunoglobulina E (IgE); Alérgenos; Lactantes.

PDF
XML

Referencias

1. Zepeda-Ortega B, Goh A, Xepapadaki P, et al. Strategies and Future Opportunities for the Prevention, Diagnosis, and Management of Cow Milk Allergy. Front Immunol 2021; 12: 1-13. doi:10.3389/fimmu.2021.608372

2. van Neerven RJJ, Savelkoul HFJ. The Two Faces of Cow’s Milk and Allergy: Induction of Cow’s Milk Allergy vs. Prevention of Asthma. Nutrients. 2019; 11 (8): 1945. doi:10.3390/nu11081945

3. Winberg A, West CE, Strinnholm Å, Nordström L, Hedman L, Rönmark E. Assessment of allergy to milk, egg, cod, and wheat in Swedish schoolchildren: A population based cohort study. PLoS One. 2015; 10 (7): 1-12. doi:10.1371/journal.pone.0131804

4. Sicherer SH, Sampson HA. Food allergy: A review and update on epidemiology, pathogenesis, diagnosis, prevention, and management. Journal of Allergy and Clinical Immunology. 2018; 141 (1): 41-58. doi:10.1016/j.jaci.2017.11.003

5. Flom JD, Sicherer SH. Epidemiology of Cow’s Milk Allergy. Nutrients. 2019; 11 (5): 1051. doi:10.3390/nu11051051

6. Navarrete LV, Calvo JB, María A, Martín P, et al. Alergia IgE mediada a proteínas de leche de vaca. Protoco Diagn ter pediatr. 2019; 2 (1):207-215.

7. Montijo-Barrios E, López-Ugalde MV, Ramírez-Mayans J, et al. Guía latinoamericana para el diagnóstico y tratamiento de alergia a las proteínas de la leche de vaca (GL-APLV). Rev Invest Clin. 2014; 66: S9-S72.

8. Mousan G, Kamat D. Cow’s Milk Protein Allergy. Clin Pediatr (Phila). 2016; 55 (11): 1054-1063. doi:10.1177/0009922816664512

9. Tsabouri S, Douros K, Priftis K. Cow’s Milk Allergenicity. Endocrine‚ Metabolic & Immune Disorders-Drug Targets. 2014; 14 (1): 16-26. doi:10.2174/1871530314666140121144224

10. Villa C, Costa J, Oliveira MBPP, Mafra I. Bovine Milk Allergens: A Comprehensive Review. Compr Rev Food Sci Food Saf. 2018; 17 (1): 137-164. doi:10.1111/1541-4337.12318

11. Adel-Patient K, Bernard H, Fenaille F, Hazebrouck S, Junot C, Verhasselt V. Prevention of Allergy to a Major Cow’s Milk Allergen by Breastfeeding in Mice Depends on Maternal Immune Status and Oral Exposure During Lactation. Front Immunol. 2020; 11: 1-10. doi:10.3389/fimmu.2020.01545

12. de La Cruz S, González I, García T, Martín R. Food allergies: The importance of food allergen management. Nutricion Clinica y Dietetica Hospitalaria. 2018; 38 (1): 142-148. doi:10.12873/381RMartin

13. Toca MC, Roman-Riechmann E, Vázquez-Frías R, et al. A Latin American and Spanish pediatric gastroenterology group’s understanding of cow’s milk protein allergy diagnosis and treatment: Results of a survey by the Food Allergy Working Group of the Sociedad Latinoamericana de Gastroenterología, Hepatología. Rev Gastroenterol Mex 2020; 85 (4): 382-389. doi:10.1016/j.rgmx.2019.08.002

14. Gabriel J, Sánchez R, Milla SP, et al. Una vision global de las reacciones adversas a alimentos: alergia e intolerancia alimentaria. Nutr Hosp. 2018; II: 1-7.

15. Antolín-Amérigo D, Rodríguez-Rodríguez M, Barbarroja-Escudero J, Sánchez-González MJ. Reacciones alérgicas a alimentos. Medicine (Spain). 2013;11 (29): 1788-1796. doi:10.1016/S0304-5412(13)70529-8

16. Savage J, Sicherer S, Wood R. The Natural History of Food Allergy. Journal of Allergy and Clinical Immunology: In Practice. 2016; 4 (2): 196-203. doi:10.1016/j.jaip.2015.11.024

17. Ortega Martell JA, Huerta Hernández RE. Diagnóstico de alergia a alimentos. Alergia, Asma e Inmunología Pediátricas. 2020; 29 (1): 31-36. doi:10.35366/93323

18. Wal JM. An update on allergens - Cow’s milk allergens. Allergy: European Journal of Allergy and Clinical Immunology. 1998; 53 (12): 1013–1022. doi:10.1111/j.1398-9995.1998.tb03830.x

19. Deng Y, Govers C, Beest E ter, van Dijk AJ, t al. A THP-1 Cell Line-Based Exploration of Immune Responses Toward Heat-Treated BLG. Front Nutr. 2021; 7: 1-14. doi:10.3389/fnut.2020.612397

20. Savina A, Amigorena S. Phagocytosis and antigen presentation in dendritic cells. Immunol Rev. 2007; 219 (1): 143-156. doi:10.1111/j.1600-065X.2007.00552.x

21. Roth-Walter F, Afify SM, Pacios LF, et al. Cow’s milk protein β-lactoglobulin confers resilience against allergy by targeting complexed iron into immune cells. Journal of Allergy and Clinical Immunology. 2021; 147 (1): 321-334.e4. doi:10.1016/j.jaci.2020.05.023

22. Vera Ch. JF, Ramírez V. A. Síntomas digestivos y respuesta clínica en lactantes con alergia a la proteína de leche de vaca. Rev Chil Pediatr. 2013; 84 (6): 641-649. doi:10.4067/S0370-41062013000600007

23. Goodman RE, Ebisawa M, Ferreira F, et al. AllergenOnline: A peer-reviewed, curated allergen database to assess novel food proteins for potential cross-reactivity. Mol Nutr Food Res. 2016; 60 (5): 1183-1198. doi:10.1002/mnfr.201500769

24. Espín Jaime B, Díaz Martín JJ, Blesa Baviera LC, et al. Alergia a las proteínas de leche de vaca no mediada por IgE: documento de consenso de la Sociedad Española de Gastroenterología, Hepatología y Nutrición Pediátrica (SEGHNP), la Asociación Española de Pediatría de Atención Primaria (AEPAP), la Sociedad Esp. An Pediatr (Engl Ed). 2019; 90 (3): 193.e1-193.e11. doi:10.1016/j.anpedi.2018.11.007

25. Nowak-Węgrzyn A, Chehade M, Groetch ME, et al. International consensus guidelines for the diagnosis and management of food protein–induced enterocolitis syndrome: Executive summary—Workgroup Report of the Adverse Reactions to Foods Committee, American Academy of Allergy, Asthma & Immunology. Journal of Allergy and Clinical Immunology. 2017; 139 (4): 1111-1126.e4. doi:10.1016/j.jaci.2016.12.966

26. AL-Iede M, Sarhan L, Alshrouf MA, Said Y. Perspectives on Non-IgE-Mediated Gastrointestinal Food Allergy in Pediatrics: A Review of Current Evidence and Guidelines. J Asthma Allergy. 2023; 16: 279-291. doi:10.2147/JAA.S284825

27. Kamal AA, Fawzia SES. Toxicological and safety assessment of tartrazine as a synthetic food additive on health biomarkers: A review. Afr J Biotechnol. 2018;17(6):139-149. doi:10.5897/ajb2017.16300

28. Montijo-Barrios E, López-Ugalde MV, Ramírez-Mayans J, et al. Guía latinoamericana para el diagnóstico y tratamiento de alergia a las proteínas de la leche de vaca (GL-APLV). Rev Invest Clin. 2014; 66: S9-S72.

29. Xepapadaki P, Fiocchi A, Grabenhenrich L, et al. Incidence and natural history of hen’s egg allergy in the first 2 years of life - The EuroPrevall birth cohort study. Allergy: Eur J Allergy Clin Immunol. 2016; 71 (3): 350-357. doi:10.1111/all.12801

30. Brough HA, Liu AH, Sicherer S, et al. Atopic dermatitis increases the effect of exposure to peanut antigen in dust on peanut sensitization and likely peanut allergy. J Allergy Clin Immunol. 2015; 135 (1): 164-170.e4. doi:10.1016/j.jaci.2014.10.007

31. Peters RL, Dharmage SC, Gurrin LC, et al. The natural history and clinical predictors of egg allergy in the first 2 years of life: A prospective, population-based cohort study. Journal of Allergy and Clinical Immunology. 2014; 133 (2): 485-491.e6. doi:10.1016/j.jaci.2013.11.032

32. Miceli Sopo S, Greco M, Monaco S, et al. Matrix effect on baked milk tolerance in children with IgE cow milk allergy. Allergol Immunopathol (Madr). 2016; 44 (6): 517-523. doi:10.1016/j.aller.2016.03.005

33. Annapure US, Gaur SS. Chapter 16 - Commercial enzymes in dairy processing. In: Kuddus M, Aguilar CNBTVA in FP and PTET, eds. Academic Press; 2022: 205-219. doi:https://doi.org/10.1016/B978-0-323-89929-1.00015-9

34. de la Fuente M, Lombardero L, Gómez-González A, et al. Enzyme therapy: Current challenges and future perspectives. Int J Mol Sci. 2021; 22 (17): 1-20. doi:10.3390/ijms22179181

35. Liang X, Yang H, Sun J, et al. Effects of enzymatic treatments on the hydrolysis and antigenicity reduction of natural cow milk. Food Sci Nutr. 2021; 9 (2): 985-993. doi:10.1002/fsn3.2066

36. Maryniak NZ, Sancho AI, Hansen EB, Bøgh KL. Alternatives to Cow’s Milk-Based Infant Formulas in the Prevention and Management of Cow’s Milk Allergy. Foods. 2022; 11 (7): 926. doi:10.3390/foods11070926

37. Candreva AM, Smaldini PL, Curciarello R, et al. Cross-reactivity Between P34 and Bovine Caseins AAIR. Allergy Asthma Immunol Res. 2015; 7 (1): 60-68.

38. Bedolla-Pulido A, Morales-Romero J, Hernández-Colín DD, Bedolla-Pulido TR, et al. Prevalence of cow´s milk allergy and lactose intolerance among Mexican late adolescents. Rev Alerg Mex. 2022; 69 (3): 105-108. doi:10.29262/ram.v69i3.1120

39. Villegas Meza PA. Prevalencia alergia a proteína leche de vaca con escala COMISS, IMPE Chihuahua, marzo a mayo 2022, serie de casos. Rev Alerg Mex. 2023; 70 (3): 192. doi:10.29262/ram.v70i3.1266

40. Vieira MC, Morais MB, Spolidoro JVN, et al. A survey on clinical presentation and nutritional status of infants with suspected cow’ milk allergy. BMC Pediatr. 2010; 10. doi:10.1186/1471-2431-10-25

41. Petriz NA, Antonietti C, Parente C, et al. Estudio epidemiológico de alergia alimentaria en una población de niños argentinos. Arch Argent Pediatr. 2020; 118 (6): 418-422. doi:10.5546/aap.2020.418

42. Cubides-Munevar AM, Linero-Terán AS, Saldarriaga-Vélez MA, Umaña-Bautista EJ, et al. Alergia a la proteína de leche de vaca. Enfoque diagnóstico y terapéutico. Rev Colomb Gastroenterol. 2020; 35 (1): 92-103. doi:10.22516/25007440.379

43. Spolidoro GCI, Amera YT, Ali MM, et al. Frequency of food allergy in Europe: An updated systematic review and meta‐analysis. Allergy. 2023; 78 (2): 351-368. doi:10.1111/all.15560

44. Schoemaker AA, Sprikkelman AB, Grimshaw KE, et al. Incidence and natural history of challenge-proven cow’s milk allergy in European children – EuroPrevall birth cohort. Allergy. 2015; 70 (8): 963-972. doi:https://doi.org/10.1111/all.12630

45. Spolidoro GCI, Ali MM, Amera YT, et al. Prevalence estimates of eight big food allergies in Europe: Updated systematic review and meta-analysis. Allergy: European Journal of Allergy and Clinical Immunology. 2023; 78 (9): 2361-2417. doi:10.1111/all.15801

46. Yamamoto-Hanada K, Pak K, Saito-Abe M, et al. Allergy and immunology in young children of Japan: The JECS cohort. World Allergy Org J. 2020; 13 (11). doi:10.1016/j.waojou.2020.100479

47. Zeng Y, Zhang J, Dong G, et al. Assessment of Cow’s milk-related symptom scores in early identification of cow’s milk protein allergy in Chinese infants. BMC Pediatr. 2019; 19 (1): 1-7. doi:10.1186/s12887-019-1563-y

48. Warren CM, Agrawal A, Gandhi D, Gupta RS. The US population-level burden of cow’s milk allergy. World Allergy Org J. 2022; 15 (4). doi:10.1016/j.waojou.2022.100644

49. Kubota K, Nagakura K, Ejiri Y, Sato S, Ebisawa M, Yanagida N. Natural history of cow’s milk allergy in children aged 6–12 years. Pediatr Allergy Immunol. 2023; 34 (12): e14064. doi:https://doi.org/10.1111/pai.14064

50. Strisciuglio C, Vitale A, Perna F, et al. Bifidobacteria modulate immune response in pediatric patients with cow’s milk protein allergy. Pediatr Res. 2023; 94 (3): 1111-1118. doi:10.1038/s41390-023-02534-0

51. Tan W, Zhou Z, Li W, Lu H, Qiu Z. Lactobacillus rhamnosus GG for Cow’s Milk Allergy in Children: A Systematic Review and Meta-Analysis. Front Pediatr. 2021; 9: 1-12. doi:10.3389/fped.2021.727127

52. Cela L, Brindisi G, Gravina A, et al. Molecular Mechanism and Clinical Effects of Probiotics in the Management of Cow’s Milk Protein Allergy. Int J Mol Sci. 2023; 24 (12). doi:10.3390/ijms24129781

53. Depoorter L, Vandenplas Y. Probiotics in pediatrics. A review and practical guide. Nutrients. 2021; 13 (7). doi:10.3390/nu13072176

54. Jing W, Liu Q, Wang W. Bifidobacterium bifidum TMC3115 ameliorates milk protein allergy in by affecting gut microbiota: A randomized double-blind control trial. J Food Biochem. 2020; 44 (11): 1-16. doi:10.1111/jfbc.13489

55. Berni Canani R, Di Costanzo M, Bedogni G, et al. Extensively hydrolyzed casein formula containing Lactobacillus rhamnosus GG reduces the occurrence of other allergic manifestations in children with cow’s milk allergy: 3-year randomized controlled trial. J Allergy Clin Immunol. 2017; 139 (6): 1906-1913.e4. doi:10.1016/j.jaci.2016.10.050

56. Jing W, Liu Q, Wang W. Bifidobacterium bifidum TMC3115 ameliorates milk protein allergy in by affecting gut microbiota: A randomized double-blind control trial. J Food Biochem. 2020; 44 (11): e13489. doi:https://doi.org/10.1111/jfbc.13489

57. Tesarschü OB. Breast milk: Functional characteristics of breast milk oligosaccharides (Part 2). Rev Chile Nutr. 2019; 46 (5): 633-643. doi:10.4067/S0717-75182019000500633

58. Sestito S, D’Auria E, Baldassarre ME, et al. The Role of Prebiotics and Probiotics in Prevention of Allergic Diseases in Infants. Front Pediatr. 2020; 8. doi:10.3389/fped.2020.583946

59. De Schryver S, Mazer B, Clarke AE, et al. Adverse Events in Oral Immunotherapy for the Desensitization of Cow’s Milk Allergy in Children: A Randomized Controlled Trial. J Allergy Clin Immunol Pract. 2019; 7 (6): 1912-1919. doi:10.1016/j.jaip.2019.02.007

60. Wood RA, Togias A, Sicherer SH, et al. Omalizumab for the Treatment of Multiple Food Allergies. N Engl J Med. 2024; 390 (10): 889-899. doi:10.1056/nejmoa2312382

61. Beaudoin M, Citron C, Brar KK. Biologics in Food Allergies: Emerging Therapies. Immunol Allergy Clin North Am. 2024; 44 (4): 645-655. doi:https://doi.org/10.1016/j.iac.2024.07.004

62. Cerecedo I, De la Hoz B, Infante S, et al. Safety, Tolerability, and Feasibility of the Milk Ladder for Reintroduction of Cow’s Milk in Infants With IgE-Mediated Cow’s Milk Allergy. J Invest Allergy Clin Immunol. 2024; 34 (6): 414-416. doi:10.18176/jiaci.1017

63. Toca MC, Morais MB, Vázquez-Frias R, et al. Consenso sobre el diagnóstico y el tratamiento de la alergia a las proteínas de la leche de vaca de la Sociedad Latinoamericana de Gastroenterología, Hepatología y Nutrición. Rev Gastroenterol Mex. 2022; 87 (2): 235-250. doi:10.1016/j.rgmx.2022.03.007

64. Ebisawa M, Ito K, Fujisawa T, et al. Japanese guidelines for food allergy 2020. Allergol Int. 2020; 69 (3): 370-386. doi:10.1016/j.alit.2020.03.004

Creative Commons License

Esta obra está bajo una licencia internacional Creative Commons Atribución-NoComercial 4.0.

Derechos de autor 2025 Revista Alergia México

##plugins.themes.healthSciences.displayStats.downloads##

##plugins.themes.healthSciences.displayStats.noStats##