<b>The impact of heat waves in allergic diseases: Group Report of the Environmental Committee of the Mexican College of Clinical Immunology and Allergy (CMICA) </b>
PDF (Spanish)
XML (Spanish)

Keywords

Heat wave
Climate change
Public health
Respiratory disease
Severe asthma
Atopic dermatitis
Pediatric patients
Mexico
Latin america
Allergic rhinitis

How to Cite

The impact of heat waves in allergic diseases: Group Report of the Environmental Committee of the Mexican College of Clinical Immunology and Allergy (CMICA) . (2025). Revista Alergia México, 72(4), 348-358. https://doi.org/10.29262/ram.v72i4.1454

Abstract

particularly in populations with allergic and respiratory diseases.

Objective: A review to describe the available evidence on the relationship between heat waves and the exacerbation of allergic diseases, with emphasis on the environmental and pathophysiological mechanisms involved.

Methods: A structured search was conducted in Scopus and Web of Science (2015–2025), complemented with regional literature, identifying 304 references. After applying inclusion and exclusion criteria, 120 full-text articles were assessed, and 79 were included in the qualitative synthesis.

Results: Evidence confirms that heat waves are associated with an increase in hospital admissions for asthma and with more frequent consultations for atopic dermatitis in pediatric patients. The mechanisms identified include intensified pollen production and dispersal, synergy with air pollutants, disruption of the epithelial barrier, and activation of transient receptor potential (TRP) channels.

Conclusions: The lack of well-defined study protocols for managing allergic patients during heat waves represents a gap not only in Mexico and Latin America but also worldwide. Key limitations include the absence of standardized definitions, the scarcity of multi-exposure analysis models, and the lack of comprehensive strategies for urban mitigation and clinical adaptation to protect the most vulnerable groups. In the case of allergic rhinitis, the available data remain inconclusive regarding exacerbations associated with heat waves.

Keywords: Heat wave; Climate change; Public health; Respiratory disease; Asthma; Atopic dermatitis; Pediatric patients; Mexico; Latin america; Allergic rhinitis.

PDF (Spanish)
XML (Spanish)

References

Smith TT, Zaitchik BF, Gohlke JM. Heat waves in the United States: definitions, patterns and trends. Climatic change. 2013; 118: 811-825. doi: 10.1007/s10584-012-0659-2

2. Wang Y, Lin L, Xu Z, et al. Have residents adapted to heat wave and cold spell in the 21st century? Evidence from 136 Chinese cities. Environment International. 2023; 173: 107811. doi:10.1016/j.envint.2023.107811

3. Trenberth AKE, Hoskins EB, Jones AP, et al. Observations: Surface and atmospheric climate change. Climate Change 2007: The Physical Science Basis: Working Group I contribution to the Fourth Assessment Report of the IPCC. 2025. https://opensky.ucar.edu/islandora/object/books%3A281

4. Witt C, Schubert AJ, Jehn M, et al. The effects of climate change on patients with chronic lung disease: a systematic literature review. Deutsches Ärzteblatt International. 2015; 112 (51-52): 878.doi: 10.3238/arztebl.2015.0878.

5. Tuerdi N, Cao X, Tang H, et al. Combined effect of heatwaves and residential greenness on the risk of stroke among Chinese adults: A national cohort study. Ecotoxicology and Environmental Safety. 2025; 299: 118356. doi:10.1016/j.ecoenv.2025.118356

6. Yin P, Chen R, Wang L, et al. The added effects of heatwaves on cause-specific mortality: A nationwide analysis in 272 Chinese cities. Environment International. 2018; 121: 898-905. doi:10.1016/j.envint.2018.10.016

7. Bunting EL, Tolmanov V, Keellings D. What is a heat wave: A survey and literature synthesis of heat wave definitions across the United States. PLOS Climate. 2024; 3 (9): e0000468. doi:10.1371/journal.pclm.0000468

8. Mason H, King JC, Peden AE, Franklin RC. Systematic review of the impact of heatwaves on health service demand in Australia. BMC Health Serv Res. 2022; 22 (1): 960. doi:10.1186/s12913-022-08341-3

9. Jáuregui E. Las ondas de calor en la Ciudad de México. Invest Geográf. 2009; (70). doi:10.14350/rig.18078

10. Barrios-Barocio A, Peralta O, Ochoa-Moya CA, et al. Heat wave: a new characterization in terms of energy. Front Environ Sci. 2024; 12: 1474608. doi:10.3389/fenvs.2024.1474608

11. Araiza-Olivares GA. La isla de calor en la Ciudad de México: un análisis decadal (1950-2010). Revista Geográfica de América Central. 2022; (69): 415-436. doi:10.15359/rgac.69/2.15

12. Navarro‐Estupiñan J, Robles‐Morua A, Vivoni ER, et al. Observed trends and future projections of extreme heat events in Sonora, Mexico. Int J Climatol. 2018; 38 (14): 5168-5181.doi:10.1002/joc.5719

13. Córdova Sáez K. Impactos de las islas térmicas o islas de calor urbano, en el ambiente y la salud humana: Análisis estacional comparativo: Caracas, octubre- 2009, marzo- 2010. Terra. 2011;27(42):95-122.

14. Demain JG, Choi YJ, Oh JW. The Impact of Climate Change on the Pollen Allergy and Sporulation of Allergic Fungi. Curr Treat Options Allerg. 2021; 8 (1): 60-73. doi:10.1007/s40521-020-00277-5

15. d’Amato G, Chong‐Neto HJ, Monge Ortega OP, et al. The effects of climate change on respiratory allergy and asthma induced by pollen and mold allergens. Allergy. 2020; 75 (9): 2219-2228. doi: 10.1111/all.14476

16. Friedlingstein P, O’Sullivan M, Jones M, et al. Global Carbon Budget 2024. Earth System Science Data. 2025; 17(3): 965-1039. doi:10.5194/essd-17-965-2025

17. Agache I, Sampath V, Aguilera J, et al. Climate change and global health: a call to more research and more action. Allergy. 2022; 77(5): 1389-1407. doi: 10.1111/all.16205

18. Perera F, Nadeau K. Climate change, fossil-fuel pollution, and children’s health. N Eng J Med. 2022; 386 (24): 2303-2314. doi: 10.1056/NEJMra2117706

19. Masson-Delmotte V, Zhai P, Pirani A, et al., eds. Climate Change 2021: The Physical Science Basis. Contribution of Working Group I to the Sixth Assessment Report of the Intergovernmental Panel on Climate Change. Cambridge University Press; 2021. doi:10.1017/9781009157896

20. D’Amato G, Vitale C, Lanza M, et al. Climate change, air pollution, and allergic respiratory diseases: an update. Curr Opin Allergy Clin Immunol. 2016; 16 (5): 434-440. doi:10.1097/ACI.0000000000000301

21. Knutson T, Chung MV, Vecchi G, et al. ScienceBrief Review: Climate change is probably increasing the intensity of tropical cyclones.2021 In: Critical Issues in Climate Change Science, edited by: Corinne Le Quéré, Peter Liss & Piers Forster. https://doi.org/10.5281/zenodo.4570334

22. Pacheco SE, Guidos-Fogelbach G, Annesi-Maesano I, et al. Climate change and global issues in allergy and immunology. J Allergy Clin Immunol. 2021; 148 (6): 1366-1377. doi: 10.1016/j.jaci.2021.10.011

23. Llamas-Velasco M, García-Díez A. Cambio climático y piel: retos diagnósticos y terapéuticos. Actas Dermo-Sifiliográficas. 2010; 101 (5): 401-410. doi: 10.1016/j.ad.2009.12.019

24. Whitman S, Good G, Donoghue E, et al. Mortality in Chicago attributed to the July 1995 heat wave. Am J Pub Health. 1997; 87 (9): 1515-1518. doi:10.2105/AJPH.87.9.1515

25. Robine JM, Cheung SLK, Le Roy S, et al. Death toll exceeded 70,000 in Europe during the summer of 2003. Comptes Rendus Biologies. 2008; 331 (2): 171-U5. doi:10.1016/j.crvi.2007.12.001

26. Organización Panamericana de la Salud (OPS). Emergencias En Salud: Ola de Calor y Medidas a Tomar – Revisión Preliminar. OPS; 2019.

27. Dunn RJH, Blannin J, Gobron N, et al. Global Climate. Bull Am Meteorol Soc. 2024; 105 (8): S12-S155. doi:10.1175/BAMS-D-24-0116.1

28. US EPA O. Climate Change Indicators: Heat Waves. 2021. https://www.epa.gov/climate-indicators/climate-change-indicators-heat-waves

29. McDonald RI, Biswas T, Sachar C, et al. The tree cover and temperature disparity in US urbanized areas: Quantifying the association with income across 5,723 communities. PloS one. 2021; 16 (4): e0249715.doi: 10.1371/journal.pone.0249715

30. Anderson GB, Bell ML. Heat Waves in the United States: Mortality Risk during Heat Waves and Effect Modification by Heat Wave Characteristics in 43 U.S. Communities. Environ Health Perspect. 2011; 119 (2): 210-218. doi:10.1289/ehp.1002313

31. Martínez-Martínez J. Estudio de la isla de calor de la ciudad de Alicante. Ingeo. 2014; (62): 83. doi:10.14198/INGEO2014.62.06

32. Barrera Alarcón IG, Caudillo Cos CA, Medina Fernández SL, et al. The surface urban heat island and its manifestation in the urban structure of Mexico City. Revista de ciencias tecnológicas. 2022; 5 (3). doi: 10.37636/recit.v5n3e227

33. Leap SR, Soled DR, Sampath V, et al. Effects of extreme weather on health in underserved communities. Ann Allergy Asthma Immunol. 2024; 133 (1): 20-27. doi:10.1016/j.anai.2024.04.018

34. Ballinas M. La isla de calor urbana y la Mitigación de la isla de calor urbana a partir de la vegetación arbórea. 2013. Publicación del Instituto de Ecología de la UNAM. https://www.researchgate.net/profile/Victor-Barradas/publication/265905412_La_isla_de_calor_urbana_y_la_vegetacion_arborea/links/542033ce0cf203f155c2b8b8/La-isla-de-calor-urbana-y-la-vegetacion-arborea.pdf

35. Jauregui E. The urban climate of Mexico City. Urban Climatology and its applications with special regard to tropical areas. In: 1984: 63-86. doi.org/10.3112/erdkunde.1973.04.06

36. Olas de calor: guía para acciones basadas en la salud. 2025. https://iris.paho.org/handle/10665.2/55244

37. Olas de calor: guía para acciones basadas en la salud - OPS/OMS | Organización Panamericana de la Salud. 2021. https://www.paho.org/es/documentos/olas-calor-guia-para-acciones-basadas-salud

38. El Khayat M, Halwani DA, Hneiny L, et al. Impacts of climate change and heat stress on farmworkers’ health: A scoping review. Front Pub Health. 2022; 10: 782811.doi: 10.3389/fpubh.2022.782811

39. Sahu S, Sett M, Kjellstrom T. Heat Exposure, Cardiovascular Stress and Work Productivity in Rice Harvesters in India: Implications for a Climate Change Future. Ind Health. 2013; 51 (4): 424-431. doi: 10.2486/indhealth.2013-0006

40. Gubernot DM, Anderson GB, Hunting KL. Characterizing Occupational Heat-Related Mortality in the United States, 2000-2010: An Analysis Using the Census of Fatal Occupational Injuries Database. Am J Ind Med. 2015; 58 (2): 203-211. doi:10.1002/ajim.22381

41. Frimpong K, Van Etten EEJ, Oosthuzien J, et al. Heat exposure on farmers in northeast Ghana. Int J Biometeorol. 2017; 61 (3): 397-406. doi:10.1007/s00484-016-1219-7

42. Menzel A, Sparks TH, Estrella N, et al. European phenological response to climate change matches the warming pattern. Glob Change Biol. 2006; 12 (10): 1969-1976. doi:10.1111/j.1365-2486.2006.01193.x

43. Marselle MR, Stadler J, Korn H, et al. Biodiversity and Health in the Face of Climate Change. Springer Nature; 2019. doi:10.1007/978-3-030-02318-8_20

44. Damialis A, Fotiou C, Halley JM, et al. Effects of environmental factors on pollen production in anemophilous woody species. Trees-Struct Funct. 2011; 25 (2): 253-264. doi:10.1007/s00468-010-0502-1

45. Beggs PJ. Environmental Allergens: from Asthma to Hay Fever and Beyond. Curr Clim Change Rep. 2015; 1 (3): 176-184. doi:10.1007/s40641-015-0018-2

46. Garcia-Mozo H, Galan C, Jato V, et al. Quercus pollen season dynamics in the Iberian Peninsula: Response to meteorological parameters and possible consequences of climate change. Ann Agr Env Med. 2006; 13 (2): 209-224.

47. Zhang Y, Steiner AL. Projected climate-driven changes in pollen emission season length and magnitude over the continental United States. Nat Commun. 2022; 13 (1): 1234. doi:10.1038/s41467-022-28764-0

48. Ziska LH, Makra L, Harry SK, et al. Temperature-related changes in airborne allergenic pollen abundance and seasonality across the northern hemisphere: a retrospective data analysis. Lancet Planetary Health. 2019; 3 (3): e124-e131. doi: 10.1016/S2542-5196(19)30219-0.

49. Tham R, Dharmage SC, Taylor PE, et al. Outdoor fungi and child asthma health service attendances. Pediatr Allergy Immunol. 2014; 25 (5): 439-449. doi:10.1111/pai.12257

50. Erbas B, Akram M, Dharmage SC, et al. The role of seasonal grass pollen on childhood asthma emergency department presentations. Clin Exp Allergy. 2012; 42 (5): 799-805. doi:10.1111/j.1365-2222.2012.03995.x

51. Rossiello MR, Szema A. Health Effects of Climate Change-induced Wildfires and Heatwaves. Cureus. 2019. doi:10.7759/cureus.4771

52. Pazmiño D. Diferencias en el clima que produce incendios forestales y de olas de calor en Victoria, Australia. Fi. 2020; 1 (1): 26-39. doi:10.29166/revfig.v1i1.1419

53. Jolly WM, Cochrane MA, Freeborn PH, et al. Climate-induced variations in global wildfire danger from 1979 to 2013. Nat Commun. 2015; 6 (1): 7537. doi:10.1038/ncomms8537

54. Vardoulakis S, Jalaludin BB, Morgan GG, et al. Bushfire smoke: urgent need for a national health protection strategy. Medical Journal of Australia. 2020; 212 (8): 349. doi:10.5694/mja2.50511

55. Williamson GJ, Bowman DMJS, Price OF, et al. A transdisciplinary approach to understanding the health effects of wildfire and prescribed fire smoke regimes. Environ Res Lett. 2016; 11 (12): 125009. doi:10.1088/1748-9326/11/12/125009

56. Grigorieva E, Lukyanets A. Combined Effect of Hot Weather and Outdoor Air Pollution on Respiratory Health: Literature Review. Atmosphere. 2021; 12 (6). doi:10.3390/atmos12060790

57. Needleman RK, Neylan IP, Erickson T. Potential environmental and ecological effects of global climate change on venomous terrestrial species in the wilderness. Wildern Environment Med. 2018; 29 (2): 226-238.doi: 10.1016/j.wem.2017.11.004

58. Demain JG, Minaei AA, Tracy JM. Anaphylaxis and insect allergy. Curr Opin Allergy Clin Immunol. 2010; 10 (4): 318-322. doi:10.1097/ACI.0b013e32833a6c72

59. Patel C, Iweala OI. ‘Doc, will I ever eat steak again?’: diagnosis and management of alpha-gal syndrome. Current Opin Pediatri. 2020;32(6):816-824. doi:10.1097/MOP.0000000000000955

60. Kenny G, Yardley J, Brown C, Sigal R, Jay O. Heat stress in older individuals and patients with common chronic diseases. Can Med Assoc J. 2010; 182 (10): 1053-1060. doi:10.1503/cmaj.081050

61. Soneja S, Jiang C, Fisher J, et al. A. Exposure to extreme heat and precipitation events associated with increased risk of hospitalization for asthma in Maryland, USA. Environment Health. 2016; 15: 1-7. doi: 10.1186/s12940-016-0142-z

62. Uibel D, Sharma R, Piontkowski D, et al. Association of ambient extreme heat with pediatric morbidity: a scoping review. Int J Biometeorol. 2022; 66 (8): 1683-1698. doi:10.1007/s00484-022-02310-5

63. Anenberg SC, Haines S, Wang E, et al. Synergistic health effects of air pollution, temperature, and pollen exposure: a systematic review of epidemiological evidence. Environ Health. 2020; 19: 130. doi:10.1186/s12940-020-00681-z

64. Monteiro A, Carvalho V, Oliveira T, et al. Excess mortality and morbidity during the July 2006 heat wave in Porto, Portugal. Int J Biometeorol. 2013; 57 (1): 155-167. doi:10.1007/S00484-012-0543-9

65. Wang T, Chiang E, Moreno-Vinasco L, et al. Particulate Matter Disrupts Human Lung Endothelial Barrier Integrity via ROS- and p38 MAPK-Dependent Pathways. Am J Resp Cell Mol Biol. 2010; 42 (4): 442-449. doi:10.1165/rcmb.2008-0402OC

66. Pelaia C, Vatrella A, Gallelli L, et al. Role of p38 Mitogen-Activated Protein Kinase in Asthma and COPD: Pathogenic Aspects and Potential Targeted Therapies. DDDT. 2021; 15: 1275-1284. doi:10.2147/DDDT.S300988

67. Sampath V, Aguilera J, Prunicki M, et al. Mechanisms of climate change and related air pollution on the immune system leading to allergic disease and asthma. Sem Immunol. 2023; 67: 101765. doi:10.1016/j.smim.2023.101765

68. Skevaki C, Nadeau KC, Rothenberg ME, et al. Impact of climate change on immune responses and barrier defense. J Allergy Clin Immunol. 2024; 153 (5): 1194-1205. doi:10.1016/j.jaci.2024.01.016

69. Heled Y, Fleischmann C, Epstein Y. Cytokines and their role in hyperthermia and heat stroke. J Basic Clin Physiol Pharmacol. 2013; 24 (2): 85-96. doi:10.1515/jbcpp-2012-0040

70. Zhang M, Ma Y, Ye X, et al. TRP (transient receptor potential) ion channel family: structures, biological functions and therapeutic interventions for diseases. Sign Transduct Targ Ther. 2023; 8 (1): 261. doi: 10.1038/s41392-023-01464-x

71. Martínez LG, Cárdenas RDS, García SV, et al. Transient receptor potential ion channels and their leading role in analgesic therapy. Rev Cubana Invest Bioméd. 2015; 34 (3): 278-288.

72. Garcia-Bertran S, Serra-Baldrich N, Baselga E, et al. Agentes externos en la dermatitis atópica: nuevos conceptos en multiprotección. Piel. 2017; 32 (6): 339-348. doi:10.1016/j.piel.2017.03.002

73. Çelebi Sözener Z, Treffeisen ER, Özdel Öztürk B, et al. Global warming and implications for epithelial barrier disruption and respiratory and dermatologic allergic diseases. J Allergy Clin Immunol. 2023; 152 (5): 1033-1046. doi:10.1016/j.jaci.2023.09.001

74. Llamas-Velasco M, García-Díez A. Cambio climático y piel: retos diagnósticos y terapéuticos. Actas Dermo-Sifiliográficas. 2010; 101 (5): 401-410. doi:10.1016/j.ad.2009.12.019

75. Chen Z, Li M, Lan T, et al. Effects of ambient temperature on atopic dermatitis and attributable health burden: a 6-year time-series study in Chengdu, China. PeerJ. 2023; 11: e15209. doi:10.7717/peerj.15209

76. Hui-Beckman J, Goleva E, Leung D, et al. The impact of temperature on the skin barrier and atopic dermatitis. Ann Allergy Asthma Immunol. 2023; 131 (6): 713-719. doi:10.1016/j.anai.2023.08.007

77. Mildner M, Jin J, Eckhart L, et al. Knockdown of Filaggrin Impairs Diffusion Barrier Function and Increases UV Sensitivity in a Human Skin Model. J Invest Dermatol. 2010; 130 (9): 2286-2294. doi:10.1038/jid.2010.115

78. Kinney PL, Ge B, Sampath V, et al. Health-based strategies for overcoming barriers to climate change adaptation and mitigation. J Allergy Clin Immunol. 2023; 152 (5): 1053-1059. doi:10.1016/j.jaci.2023.09.012

79. Bienestar I de S para el. Día Mundial de la Alergia | 8 de julio. gob.mx. Accessed September 24, 2025. http://www.gob.mx/insabi/articulos/dia-mundial-de-la-alergia-8-de-julio?idiom=es

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

Copyright (c) 2025 Revista Alergia México

Downloads

Download data is not yet available.