Follow-up of patients after COVID-19 pneumonia. Pulmonary sequelae

Versions

Keywords

follow-up
pneumonia
COVID-19
sequelae
pulmonary function tests

How to Cite

Follow-up of patients after COVID-19 pneumonia. : Pulmonary sequelae. (2021). Revista Alergia México. https://doi.org/10.29262/ram.v67i4.847

Abstract

Coronavirus disease 2019 (COVID-19) is an infection caused by the SARS-CoV-2. COVID-19 has caused an unprecedented pandemic, with a large number of infections and deaths worldwide. Although most cases are mild, there are a considerable number of patients who develop pneumonia or even acute respiratory distress syndrome (ARDS). After recovering from the initial disease, many patients continue with various symptoms (fatigue, dry cough, fever, dyspnea, anosmia, chest pain, among others.), which has led to consider the possible existence of the “post COVID-19 syndrome”. Although the definition and validity of this syndrome are not clear, several studies report that individuals recovered from COVID-19 may have persistent symptoms, radiological abnormalities, and compromised respiratory function. Current evidence suggests that there is a large number of pulmonary sequelae after COVID-19 pneumonia (interstitial thickening, ground glass infiltrate, crazy paving pattern, bronchiectasis, among others.). Likewise, it seems that pulmonary function tests (spirometry, DLCO, 6MWT and the measurement of maximum respiratory pressures) in addition to high-resolution computed tomography are useful for the evaluation of these post-COVID-19 pulmonary sequelae. This review aims to describe the possible pulmonary sequelae after COVID-19 pneumonia, while suggesting diagnostic procedures for their correct evaluation and follow-up; thus, allowing a proper management by a multidisciplinary medical team.

References

Muertes por COVID19 en América Latina y el Caribe. Statista. Accessed November 30, 2020. https://es.statista.com/estadisticas/1105336/covid-19-numero-fallecidos-america-latina-caribe/

Machhi J, Herskovitz J, Senan AM, et al. The Natural History, Pathobiology, and Clinical Manifestations of SARS-CoV-2 Infections. J Neuroimmune Pharmacol. Published online July 21, 2020:1-28. doi:10.1007/s11481-020-09944-5

Wang D, Hu B, Hu C, et al. Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus–Infected Pneumonia in Wuhan, China. JAMA. 2020;323(11):1061. doi:10.1001/jama.2020.1585

Greenhalgh T, Knight M, A’Court C, Buxton M, Husain L. Management of post-acute covid-19 in primary care. BMJ. Published online August 11, 2020:m3026. doi:10.1136/bmj.m3026

Hui DS, Joynt GM, Wong KT, et al. Impact of severe acute respiratory syndrome (SARS) on pulmonary function, functional capacity and quality of life in a cohort of survivors. Thorax. 2005;60(5):401-409. doi:10.1136/thx.2004.030205

Das KM, Lee EY, Singh R, et al. Follow-up chest radiographic findings in patients with MERS-CoV after recovery. Indian J Radiol Imaging. 2017;27(3):342-349. doi:10.4103/ijri.IJRI_469_16

Hui DS, Wong KT, Ko FW, et al. The 1-year impact of severe acute respiratory syndrome on pulmonary function, exercise capacity, and quality of life in a cohort of survivors. Chest. 2005;128(4):2247-2261. doi:10.1378/chest.128.4.2247

Ong K-C, Ng AW-K, Lee LS-U, et al. 1-Year Pulmonary Function and Health Status in Survivors of Severe Acute Respiratory Syndrome. Chest. 2005;128(3):1393-1400. doi:10.1378/chest.128.3.1393

Zhang P, Li J, Liu H, et al. Long-term bone and lung consequences associated with hospital-acquired severe acute respiratory syndrome: a 15-year follow-up from a prospective cohort study. Bone Res. 2020;8(1):1-8. doi:10.1038/s41413-020-0084-5

Xie L, Liu Y, Xiao Y, et al. Follow-up study on pulmonary function and lung radiographic changes in rehabilitating severe acute respiratory syndrome patients after discharge. Chest. 2005;127(6):2119-2124. doi:10.1378/chest.127.6.2119

Ngai JC, Ko FW, Ng SS, To K-W, Tong M, Hui DS. The long-term impact of severe acute respiratory syndrome on pulmonary function, exercise capacity and health status. Respirol Carlton Vic. 2010;15(3):543-550. doi:10.1111/j.1440-1843.2010.01720.x

Huang Y, Tan C, Wu J, et al. Impact of coronavirus disease 2019 on pulmonary function in early convalescence phase. Respir Res. 2020;21(1):163. doi:10.1186/s12931-020-01429-6

Frija-Masson J, Debray M-P, Gilbert M, et al. Functional characteristics of patients with SARS-CoV-2 pneumonia at 30 days post-infection. Eur Respir J. 2020;56(2). doi:10.1183/13993003.01754-2020

Mo X, Jian W, Su Z, et al. Abnormal pulmonary function in COVID-19 patients at time of hospital discharge. Eur Respir J. 2020;55(6). doi:10.1183/13993003.01217-2020

Zhao Y, Shang Y, Song W, et al. Follow-up study of the pulmonary function and related physiological characteristics of COVID-19 survivors three months after recovery. EClinicalMedicine. 2020;25:100463. doi:10.1016/j.eclinm.2020.100463

Tabernero Huguet E, A UG, La RI, et al. Pulmonary Function in Early Follow-up of patients with COVID-19 Pneumonia. Arch Bronconeumol. Published online August 1, 2020. doi:10.1016/j.arbres.2020.07.017

Tenforde MW. Symptom Duration and Risk Factors for Delayed Return to Usual Health Among Outpatients with COVID-19 in a Multistate Health Care Systems Network — United States, March–June 2020. MMWR Morb Mortal Wkly Rep. 2020;69. doi:10.15585/mmwr.mm6930e1

Carvalho-Schneider C, Laurent E, Lemaignen A, et al. Follow-up of adults with noncritical COVID-19 two months after symptom onset. Clin Microbiol Infect. 2020;0(0). doi:10.1016/j.cmi.2020.09.052

Garrigues E, Janvier P, Kherabi Y, et al. Post-discharge persistent symptoms and health-related quality of life after hospitalization for COVID-19. J Infect. 2020;0(0). doi:10.1016/j.jinf.2020.08.029

Halpin SJ, McIvor C, Whyatt G, et al. Postdischarge symptoms and rehabilitation needs in survivors of COVID-19 infection: A cross-sectional evaluation. J Med Virol. n/a(n/a). doi:https://doi.org/10.1002/jmv.26368

Hwang DM, Chamberlain DW, Poutanen SM, Low DE, Asa SL, Butany J. Pulmonary pathology of severe acute respiratory syndrome in Toronto. Mod Pathol Off J U S Can Acad Pathol Inc. 2005;18(1):1-10. doi:10.1038/modpathol.3800247

Kligerman SJ, Franks TJ, Galvin JR. From the Radiologic Pathology Archives: Organization and Fibrosis as a Response to Lung Injury in Diffuse Alveolar Damage, Organizing Pneumonia, and Acute Fibrinous and Organizing Pneumonia. RadioGraphics. 2013;33(7):1951-1975. doi:10.1148/rg.337130057

Wang Y, Jin C, Wu CC, et al. Organizing Pneumonia of COVID-19: Time-Dependent Evolution and Outcome in CT Findings. Radiology and Imaging; 2020. doi:10.1101/2020.05.22.20109934

Copin M-C, Parmentier E, Duburcq T, Poissy J, Mathieu D, Lille COVID-19 ICU and Anatomopathology Group. Time to consider histologic pattern of lung injury to treat critically ill patients with COVID-19 infection. Intensive Care Med. 2020;46(6):1124-1126. doi:10.1007/s00134-020-06057-8

Kory P, Kanne JP. SARS-CoV-2 organising pneumonia: ‘Has there been a widespread failure to identify and treat this prevalent condition in COVID-19?’ Open Access.:4.

Awulachew E, Diriba K, Anja A, Getu E, Belayneh F. Computed Tomography (CT) Imaging Features of Patients with COVID-19: Systematic Review and Meta-Analysis. Radiology Research and Practice. doi:https://doi.org/10.1155/2020/1023506

Kanne JP, Little BP, Chung JH, Elicker BM, Ketai LH. Essentials for Radiologists on COVID-19: An Update-Radiology Scientific Expert Panel. Radiology. 2020;296(2):E113-E114. doi:10.1148/radiol.2020200527

Yang W, Sirajuddin A, Zhang X, et al. The role of imaging in 2019 novel coronavirus pneumonia (COVID-19). Eur Radiol. Published online April 15, 2020:1-9. doi:10.1007/s00330-020-06827-4

Guan C-S, Wei L-G, Xie R-M, et al. CT findings of COVID-19 in follow-up: comparison between progression and recovery. Diagn Interv Radiol. 2020;26(4):301-307. doi:10.5152/dir.2019.20176

Varga Z, Flammer AJ, Steiger P, et al. Endothelial cell infection and endotheliitis in COVID-19. The Lancet. 2020;395(10234):1417-1418. doi:10.1016/S0140-6736(20)30937-5

Molina-Molina M. Secuelas y consecuencias de la COVID-19. :7.

Sibila O, Molina-Molina M, Valenzuela C, et al. Documento de consenso de la Sociedad Española de Neumología y Cirugía Torácica (SEPAR) para el seguimiento clínico post-COVID-19. Open Respir Arch. Published online October 2020:S2659663620300771. doi:10.1016/j.opresp.2020.09.002

George PM, Barratt SL, Condliffe R, et al. Respiratory follow-up of patients with COVID-19 pneumonia. Thorax. 2020;75(11):1009-1016. doi:10.1136/thoraxjnl-2020-215314

Pellegrino R, Viegi G, Brusasco V, et al. Interpretative strategies for lung function tests. Eur Respir J. 2005;26(5):948-968. doi:10.1183/09031936.05.00035205

Gochicoa-Rangel L, Torre-Bouscoulet L, Salles Rojas A, et al. Functional Respiratory Evaluation in the COVID-19 Era: The Role of Pulmonary Function Test Laboratories. Rev Investig Cl�nica. Published online October 21, 2020:4444. doi:10.24875/RIC.20000250

Graham BL, Steenbruggen I, Miller MR, et al. Standardization of Spirometry 2019 Update. An Official American Thoracic Society and European Respiratory Society Technical Statement. Am J Respir Crit Care Med. 2019;200(8):e70-e88. doi:10.1164/rccm.201908-1590ST

Mora-Romero U de J, Gochicoa-Rangel L, Guerrero-Zúñiga S, et al. Presiones inspiratoria y espiratoria máximas: Recomendaciones y procedimiento. NCT Neumol Cir Tórax. 2019;78(S2):135-141. doi:10.35366/NTS192F

Graham BL, Brusasco V, Burgos F, et al. 2017 ERS/ATS standards for single-breath carbon monoxide uptake in the lung. Eur Respir J. 2017;49(1). doi:10.1183/13993003.00016-2016

Holland AE, Spruit MA, Troosters T, et al. An official European Respiratory Society/American Thoracic Society technical standard: field walking tests in chronic respiratory disease. Eur Respir J. 2014;44(6):1428-1446. doi:10.1183/09031936.00150314

Gochicoa-Rangel L, Mora-Romero U, Guerrero-Zúñiga S, et al. Prueba de caminata de 6 minutos: recomendaciones y procedimientos. Neumol Cir Torax. 2015;74(2):10.

Vargas-Domínguez C, Mejía-Alfaro R, Martínez-Andrade R, Silva-Cerón M, Vázquez-García JC, Torre-Bouscoulet L. Prueba de desaturación y titulación de oxígeno suplementario. Recomendaciones y procedimientos. NCT Neumol Cir Tórax. 2019;78(S2):187-197. doi:10.35366/NTS192L

Hani C, Trieu NH, Saab I, et al. COVID-19 pneumonia: A review of typical CT findings and differential diagnosis. Diagn Interv Imaging. 2020;101(5):263-268. doi:10.1016/j.diii.2020.03.014

Jalaber C, Lapotre T, Morcet-Delattre T, Ribet F, Jouneau S, Lederlin M. Chest CT in COVID-19 pneumonia: A review of current knowledge. Diagn Interv Imaging. 2020;101(7-8):431-437. doi:10.1016/j.diii.2020.06.001

Han R, Huang L, Jiang H, Dong J, Peng H, Zhang D. Early Clinical and CT Manifestations of Coronavirus Disease 2019 (COVID-19) Pneumonia. AJR Am J Roentgenol. 2020;215(2):338-343. doi:10.2214/AJR.20.22961

Liu K-C, Xu P, Lv W-F, et al. CT manifestations of coronavirus disease-2019: A retrospective analysis of 73 cases by disease severity. Eur J Radiol. 2020;126:108941. doi:10.1016/j.ejrad.2020.108941

Caruso D, Zerunian M, Polici M, et al. Chest CT Features of COVID-19 in Rome, Italy. Radiology. 2020;296(2):E79-E85. doi:10.1148/radiol.2020201237

Kaufman AE, Naidu S, Ramachandran S, Kaufman DS, Fayad ZA, Mani V. Review of radiographic findings in COVID-19. World J Radiol. 2020;12(8):142-155. doi:10.4329/wjr.v12.i8.142

Prokop M, van Everdingen W, van Rees Vellinga T, et al. CO-RADS: A Categorical CT Assessment Scheme for Patients Suspected of Having COVID-19—Definition and Evaluation. Radiology. 2020;296(2):E97-E104. doi:10.1148/radiol.2020201473

Pan F, Ye T, Sun P, et al. Time Course of Lung Changes On Chest CT During Recovery From 2019 Novel Coronavirus (COVID-19) Pneumonia. Radiology. Published online February 13, 2020. doi:10.1148/radiol.2020200370

Combet M, Pavot A, Savale L, Humbert M, Monnet X. Rapid onset honeycombing fibrosis in spontaneously breathing patient with COVID-19. Eur Respir J. 2020;56(2). doi:10.1183/13993003.01808-2020

Kayhan S, Kocakoç E. Pulmonary Fibrosis Due to COVID-19 Pneumonia. Korean J Radiol. 2020;21(11):1273. doi:10.3348/kjr.2020.0707

Ojo AS, Balogun SA, Williams OT, Ojo OS. Pulmonary Fibrosis in COVID-19 Survivors: Predictive Factors and Risk Reduction Strategies. Pulm Med.:10.

Mazza MG, De Lorenzo R, Conte C, et al. Anxiety and depression in COVID-19 survivors: Role of inflammatory and clinical predictors. Brain Behav Immun. 2020;89:594-600. doi:10.1016/j.bbi.2020.07.037

Cuijpers P, Vogelzangs N, Twisk J, Kleiboer A, Li J, Penninx BW. Comprehensive meta-analysis of excess mortality in depression in the general community versus patients with specific illnesses. Am J Psychiatry. 2014;171(4):453-462. doi:10.1176/appi.ajp.2013.13030325

Spruit MA, Holland AE, Singh SJ, Tonia T, Wilson KC, Troosters T. COVID-19: Interim Guidance on Rehabilitation in the Hospital and Post-Hospital Phase from a European Respiratory Society and American Thoracic Society-coordinated International Task Force. Eur Respir J. Published online January 1, 2020. doi:10.1183/13993003.02197-2020

Bai C, Chotirmall SH, Rello J, et al. Updated guidance on the management of COVID-19: from an American Thoracic Society/European Respiratory Society coordinated International Task Force (29 July 2020). Eur Respir Rev. 2020;29(157). doi:10.1183/16000617.0287-2020

Chérrez-Ojeda I, Vanegas E, Felix M. The unusual experience of managing a severe COVID-19 case at home: what can we do and where do we go? BMC Infect Dis. 2020;20(1):862. doi:10.1186/s12879-020-05608-0

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

Copyright (c) 2021 Revista Alergia México

Downloads

Download data is not yet available.