<b>Mortalidad por asma en Colombia: análisis de tres décadas y efecto de la pandemia por COVID-19</b>
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Palabras clave

Asma
COVID-19
Global Burden of Disease
PRevalencia
Colombia
Enfermedades crónicas
Salud pública
Emergencia

Cómo citar

Mortalidad por asma en Colombia: análisis de tres décadas y efecto de la pandemia por COVID-19. (2026). Revista Alergia México, 73(2), 137-152. https://doi.org/10.29262/ram.v73i2.1597

Resumen

OBJETIVOS: Analizar las tendencias de mortalidad por asma en Colombia entre 1990 y 2021, y evaluar la repercusión de la pandemia por COVID-19 durante el período 2020-2021.

MÉTODOS: Estudio retrospectivo y observacional, llevado a cabo a partir del análisis datos del Global Burden of Disease 2021 para estimar la prevalencia, mortalidad y años de vida ajustados por discapacidad (DALYs), estandarizados por edad en Colombia. Adicionalmente, se analizaron los registros de mortalidad cruda por asma correspondientes al período 2015-2023 del Departamento Administrativo Nacional de Estadística (DANE). Las tendencias temporales se evaluaron mediante regresión Joinpoint y se compararon las tasas de mortalidad cruda antes y durante la pandemia para estimar la mortalidad en exceso.

RESULTADOS: Se observó una disminución significativa de la mortalidad por asma en Colombia entre 1990 y 2021 (AAPC: −1.5%; IC95%: −1.7 a −1.3), similar a la tendencia mundial. Sin embargo, durante 2020-2021 la mortalidad por asma se incrementó de 0.43 a 0.63 por cada 100,000 habitantes versus 2015-2019 (RR = 1.49; CI95%: 1.35-1.64), con un incremento relativo mayor en personas mayores de 65 años.

CONCLUSIONES: A pesar de la reducción sostenida de mortalidad por asma en Colombia durante tres décadas, la pandemia por COVID-19 se asoció con aumento significativo de las defunciones por esta causa, lo que resalta la necesidad de garantizar la continuidad de atención por enfermedades crónicas durante periodos de emergencia de salud pública.

PALABRAS CLAVE: Asma; Pandemia por COVID-19; Global Burden of Disease; Prevalencia; Colombia; Enfermedades crónicas; Salud pública; Emergencia.

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Referencias

1. Cao Y, Chen S, Chen X, Zou W, et al. Global trends in the incidence and mortality of asthma from 1990 to 2019: An age-period-cohort analysis using the global burden of disease study 2019. Front Public Health 2022; 10: 1036674. https://doi.org/10.3389/fpubh.2022.1036674.

2. GBD 2021 Asthma and Allergic Diseases Collaborators. Global, regional, and national burden of asthma and atopic dermatitis, 1990-2021, and projections to 2050: a systematic analysis of the Global Burden of Disease Study 2021. Lancet Respir Med 2025; 13: 425-46. https://doi.org/10.1016/S2213-2600(25)00003-7.

3. Ye W, Xu X, Ding Y, Li X, et al. Trends in disease burden and risk factors of asthma from 1990 to 2019 in Belt and Road Initiative countries: evidence from the Global Burden of Disease Study 2019. Ann Med 2024; 56: 2399964. https://doi.org/10.1080/07853890.2024.2399964.

4. Pizzichini MMM, Cruz ÁA, Pizzichini E. Is asthma mortality decreasing or increasing in Brazil? The burden of proof. J Bras Pneumol 2024; 50: e20240355. https://doi.org/10.36416/1806-3756/e20240355.

5. Msemburi W, Karlinsky A, Knutson V, Aleshin-Guendel S, et al. The WHO estimates of excess mortality associated with the COVID-19 pandemic. Nature 2023; 613: 130-7. https://doi.org/10.1038/s41586-022-05522-2.

6. Wang H, Paulson KR, Pease SA, Watson S, et al. Estimating excess mortality due to the COVID-19 pandemic: a systematic analysis of COVID-19-related mortality, 2020–21. Lancet 2022; 399: 1513-36. https://doi.org/10.1016/S0140-6736(21)02796-3.

7. Ren J, Pang W, Luo Y, Cheng D, et al. Impact of Allergic Rhinitis and Asthma on COVID-19 Infection, Hospitalization, and Mortality. J Allergy Clin Immunol Pract 2022; 10: 124-33. https://doi.org/10.1016/j.jaip.2021.10.049.

8. Sunjaya AP, Allida SM, Di Tanna GL, Jenkins CR. Asthma and COVID-19 risk: a systematic review and meta-analysis. Eur Respir J 2022; 59: 2101209. https://doi.org/10.1183/13993003.01209-2021.

9. Ferrari AJ, Santomauro DF, Aali A, Abate YH, et al. Global incidence, prevalence, years lived with disability (YLDs), disability-adjusted life-years (DALYs), and healthy life expectancy (HALE) for 371 diseases and injuries in 204 countries and territories and 811 subnational locations, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021. Lancet 2024; 403: 2133-61. https://doi.org/10.1016/S0140-6736(24)00757-8.

10. DANE. Births and Deaths 2025;https://www.dane.gov.co/index.php/estadisticas-por-tema/demografia-y-poblacion/nacimientos-y-defunciones.

11. Population projections 2025. www.dane.gov.co/index.php/en/statistics-by-topic-1/population-and-demography/population-projections.

12. Kim H-J, Chen H-S, Byrne J, Wheeler B, Feuer EJ. Twenty years since Joinpoint 1.0: Two major enhancements, their justification, and impact. Stat Med 2022; 41: 3102-30. https://doi.org/10.1002/sim.9407.

13. Kim HJ, Fay MP, Feuer EJ, Midthune DN. Permutation tests for joinpoint regression with applications to cancer rates. Stat Med 2000; 19: 335-51. https://doi.org/10.1002/(sici)1097-0258(20000215)19:3%253C335::aid-sim336%253E3.0.co;2-z.

14. Tapper EB, Parikh ND. Mortality due to cirrhosis and liver cancer in the United States, 1999-2016: observational study. BMJ 2018; 362: k2817. https://doi.org/10.1136/bmj.k2817.

15. Vergara C, Caraballo L. Asthma mortality in Columbia. Ann Allergy Asthma Immunol 1998; 80: 55-60. https://doi.org/10.1016/s1081-1206(10)62940-7.

16. Gyawali B, Georas SN, Khurana S. Biologics in severe asthma: a state-of-the-art review. Eur Respir Rev 2025; 34: 240088. https://doi.org/10.1183/16000617.0088-2024.

17. Neto AC, Filho OFF, Bueno T. Brazilian examples of programs for the control of asthma. J Bras Pneumol 2008; 34: 103-6. https://www.scielo.br/j/jbpneu/a/j8vgpqhbkdNQg3whVT9VzcB/?lang=pt

18. Departamento Nacional de Planeación. Population Health Coverage in Colombia 2018. https://www.dnp.gov.co/LaEntidad_/subdireccion-general-prospectiva-desarrollo-nacional/direccion-desarrollo-social/Paginas/aseguramiento-de-poblacion.aspx.

19. Urrutia-Pereira M, Chong-Neto HJ, Annesi Maesano I, Ansotegui IJ, et al. Environmental contributions to the interactions of COVID-19 and asthma: A secondary publication and update. World Allergy Organ J 2022; 15: 100686. https://doi.org/10.1016/j.waojou.2022.100686.

20. Kang Q, Yau YK, Hu Z, Quan J, et al. The Indirect Impact of COVID-19 Pandemic on Mortality, Complications, and Healthcare Utilization Among Patients With Chronic Respiratory Diseases in Hong Kong: An Interrupted Time Series Analysis. J Evid Based Med 2025; 18: e70039. https://doi.org/10.1111/jebm.70039.

21. Stadhouders L, Hoogteijling EM, Duijts L, Lebon A. Trends in asthma exacerbations in children before, during, and after the COVID-19 pandemic. Epidemiol Infect 2025; 153: e138. https://doi.org/10.1017/S0950268825100800.

22. Brum M, Henz J, Boeira M, Soares S, Friedrich F, Pitrez PM. Recent increase in asthma mortality in Brazil: a warning sign for the public health system. J Bras Pneumol 2024; 50: e20240138. https://doi.org/10.36416/1806-3756/e20240138.

23. Pinheiro DHA, Souza JVH de, Justo AFO, Carvalho-Pinto RM, et al. Asthma in the Brazilian Unified Health Care System: an epidemiological analysis from 2008 to 2021. J Bras Pneumol 2024; 50: e20230364. https://doi.org/10.36416/1806-3756/e20230364.

24. Kamal BJ, Khalaf MA. Impact of COVID-19 on asthma control in Kirkuk City: an analysis of post-pandemic trends. J Med Life 2024; 17: 292-5. https://doi.org/10.25122/jml-2023-0175.

25. Wang L, Foer D, Zhang Y, Karlson EW, et al. Post-Acute COVID-19 Respiratory Symptoms in Patients With Asthma: An Electronic Health Records-Based Study. J Allergy Clin Immunol Pract 2023; 11: 825-835.e3. https://doi.org/10.1016/j.jaip.2022.12.003.

26. Kabil NK, Karadoğan D, Telatar TG, Kaya İ, et al. Post-COVID-19 Physical Activity and Symptom Burden in Patients with Asthma and COPD Compared with Individuals Without Chronic Disease: A Multicenter Cross-Sectional Study. Diagnostics 2026; 16. https://doi.org/10.3390/diagnostics16040604.

27. Hung C-T, Hung Y-C, Suk C-W, Wu C-H. Evaluating the associations among asthma, asthma control and long COVID in U.S. adults. Infection 2025; 53: 2523-31. https://doi.org/10.1007/s15010-025-02588-8.

28. Lozano A, Salcedo-Mejia F, Dueñas C, Fernandez JC, et al. Prevalence of post-COVID symptoms in a cohort of hospitalized patients in the North Coast of Colombia (Pre-print) 2024. https://doi.org/10.21203/rs.3.rs-3898490/v1.

29. Patel O, Syamlal G, Wood J, Dodd KE, et al. Asthma Mortality Among Persons Aged 15-64 Years, by Industry and Occupation - United States, 1999-2016. MMWR Morb Mortal Wkly Rep 2018; 67: 60-65. https://doi.org/10.15585/mmwr.mm6702a2.

30. Orozco-Levi M, Borrero L, Botero L, Londoño S, Saenz S. Distribución de la prevalencia de asma registrada en Colombia. Rev Colombiana Neumol 2023. https://revistas.asoneumocito.org/index.php/rcneumologia/article/view/821.

31. Bhuia MR, Islam MA, Nwaru BI, Weir CJ, et al. Models for estimating and projecting global, regional and national prevalence and disease burden of asthma: a systematic review. J Glob Health 2020; 10: 020409. https://doi.org/10.7189/jogh.10.020409.

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Derechos de autor 2026 Revista Alergia México

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